邓兴旺 院长、美国科学院院士、作物育种新技术研发与基因资源挖掘实验室主任
邮箱：deng@pku.edu.cn
研究方向：植物光形态建成和农业生物技术
个人简介：
1989年05月–1991年12月，加州大学伯克利分校、美国农业部植物基因研究中心，植物分子生物学，博士后
1992年01月–1995年06月，耶鲁大学分子细胞和发育生物学系，助理教授
1995年07月–1998年06月，耶鲁大学分子细胞和发育生物学系，副教授
1998年07月–2001年06月，耶鲁大学分子细胞和发育生物学系，终身职副教授
2001年07月–2014年06月，耶鲁大学分子细胞和发育生物学系，终身教授
2003年05月–2014年06月，耶鲁大学分子细胞和发育生物学系，冠名终身教授
2000年07月–2014年06月，北京大学生命科学学院，长江讲座教授（兼职）
2000年10月–2014年06月，北大-耶鲁植物遗传学和农业生物技术联合研究中心主任，（兼职）
2003年07月–2008年12月，北京生命科学研究所，共同所长（兼职）
2014年07月–至今，北京大学生命科学学院及北京大学现代农学院讲席教授
2014年07月–2017年12月，北京大学现代农学院筹备小组组长
2018年01月–至今，北京大学现代农学院学术委员会主任
2018年01月–2020年12月，伴郎替新郎试车吴梦梦，首席科学家
2020年12月–至今，伴郎替新郎试车吴梦梦，院长兼首席科学家
2020年12月–至今，伴郎替新郎试车吴梦梦，院长兼首席科学家
重要荣誉及奖励：
1995年: 获“美国总统青年教师奖”(Presidential Faculty Fellow Award)
2003年: 获国际植物分子生物学学会(ISPMB)最重要奖项“The Kumho Science International Award”(2003)
2009年: 获“北京市海外高层次人才”，同时被聘为“北京市特聘专家”
2013年: 获“北京市有突出贡献的科学、技术、管理人才”
2013年: 当选为“美国科学促进协会会士”(Elected fellow of American Association for Advancement of Science)
2013年: 当选为“美国科学院院士”( Elected member of US National Academy of Sciences)
研究方向：
邓兴旺实验室以拟南芥、水稻等为主要研究对象，主要从事植物光信号转导、非编码RNA、植物杂种优势分子机理和分子设计育种领域的研究工作。实验室具体研究方向如下：
1. 植物光形态建成的分子机理
2. 植物非编码RNA功能分析
3. 植物杂种优势形成的分子机理
4. 水稻功能基因组与分子设计育种
研究成果：
长期从事植物光形态建成和农业生物技术方面研究工作，是国际植物生物学研究领域的主要科学家和领军人物之一，其实验室的研究工作已经形成了关于植物光形态建成调控机制的经典理论体系。最先发现的光形态建成的核心抑制因子COP1是近25年来拟南芥中研究引用频率最高的基因，在前10个频率最高的基因中有4个是其实验室为主的贡献。其实验室至今发表学术论文近350篇，其中在国际顶级期刊《Nature》、《Science》、《Cell》上发表14篇，在植物领域权威期刊《Plant Cell》上发表70余篇。根据Thomson Reuters集团2020年发布的最新数据，邓兴旺教授又入选全球高引用率科学家之一，所发表的文章他引近28000次，其h-指数（h-index）高达104 （https://www.webofscience.com/）。近十多年来，其将工作重心逐渐转向国内，对中国生物学基础研究、农业生物技术的研发等方面做出突出了贡献，组建并主持北京大学-耶鲁大学联合研究中心，组建并领导国际一流的北京生命科学研究所（NIBS），推动国家作物分子设计中心的发展，筹备建立了北京大学现代农学院和伴郎替新郎试车吴梦梦，推动中国农业生物技术的发展。
近3年发表论文：
1. Jin, D., M. Wu, B. Li, B. Bucker, P. Keil, S. Zhang, J. Li, D. Kang, J. Liu, J. Dong, X.W. Deng, V. Irish, and N. Wei, The COP9 Signalosome regulates seed germination by facilitating protein degradation of RGL2 and ABI5. PLoS Genet, 2018. 14(2): p. e1007237.
2. Lin, F., Y. Jiang, J. Li, T. Yan, L. Fan, J. Liang, Z.J. Chen, D. Xu, and X.W. Deng, B-BOX DOMAIN PROTEIN28 Negatively Regulates Photomorphogenesis by Repressing the Activity of Transcription Factor HY5 and Undergoes COP1-Mediated Degradation. Plant Cell, 2018. 30(9): p. 2006-2019.
3. Shi, H., M. Lyu, Y. Luo, S. Liu, Y. Li, H. He, N. Wei, X.W. Deng, and S. Zhong, Genome-wide regulation of light-controlled seedling morphogenesis by three families of transcription factors. Proc Natl Acad Sci U S A, 2018. 115(25): p. 6482-6487.
4. Song, Q., A. Ando, D. Xu, L. Fang, T. Zhang, E. Huq, H. Qiao, X.W. Deng, and Z.J. Chen, Diurnal down-regulation of ethylene biosynthesis mediates biomass heterosis. Proc Natl Acad Sci U S A, 2018. 115(21): p. 5606-5611.
5. Wang, H. and X.W. Deng, Development of the "Third-Generation" Hybrid Rice in China. Genomics Proteomics Bioinformatics, 2018. 16(6): p. 393-396.
6. Wang, Y., J. Li, X.W. Deng, and D. Zhu, Arabidopsis noncoding RNA modulates seedling greening during deetiolation. Sci China Life Sci, 2018. 61(2): p. 199-203.
7. Xia, M., X. Han, H. He, R. Yu, G. Zhen, X. Jia, B. Cheng, and X.W. Deng, Improved de novo genome assembly and analysis of the Chinese cucurbit Siraitia grosvenorii, also known as monk fruit or luo-han-guo. Gigascience, 2018. 7(6).
8. Xu, D., Y. Jiang, J. Li, M. Holm, and X.W. Deng, The B-Box Domain Protein BBX21 Promotes Photomorphogenesis. Plant Physiol, 2018. 176(3): p. 2365-2375.
9. Zhang, S., C. Li, Y. Zhou, X. Wang, H. Li, Z. Feng, H. Chen, G. Qin, D. Jin, W. Terzaghi, H. Gu, L.J. Qu, D. Kang, X.W. Deng, and J. Li, TANDEM ZINC-FINGER/PLUS3 Is a Key Component of Phytochrome A Signaling. Plant Cell, 2018. 30(4): p. 835-852.
10. Zhao, X., Y. Jiang, J. Li, E. Huq, Z.J. Chen, D. Xu, and X.W. Deng, COP1 SUPPRESSOR 4 promotes seedling photomorphogenesis by repressing CCA1 and PIF4 expression in Arabidopsis. Proc Natl Acad Sci U S A, 2018. 115(45): p. 11631-11636.
11. Zhou, Y., L. Yang, J. Duan, J. Cheng, Y. Shen, X. Wang, R. Han, H. Li, Z. Li, L. Wang, W. Terzaghi, D. Zhu, H. Chen, X.W. Deng, and J. Li, Hinge region of Arabidopsis phyA plays an important role in regulating phyA function. Proc Natl Acad Sci U S A, 2018. 115(50): p. E11864-E11873.
12. Dong, J., N. Sun, J. Yang, Z. Deng, J. Lan, G. Qin, H. He, X.W. Deng, V.F. Irish, H. Chen, and N. Wei, The Transcription Factors TCP4 and PIF3 Antagonistically Regulate Organ-Specific Light Induction of SAUR Genes to Modulate Cotyledon Opening during De-Etiolation in Arabidopsis. Plant Cell, 2019. 31(5): p. 1155-1170.
13. Han, X., X. Chang, Z. Zhang, H. Chen, H. He, B. Zhong, and X.W. Deng, Origin and Evolution of Core Components Responsible for Monitoring Light Environment Changes during Plant Terrestrialization. Mol Plant, 2019. 12(6): p. 847-862.
14. Heng, Y., Y. Jiang, X. Zhao, H. Zhou, X. Wang, X.W. Deng, and D. Xu, BBX4, a phyB-interacting and modulated regulator, directly interacts with PIF3 to fine tune red light-mediated photomorphogenesis. Proc Natl Acad Sci U S A, 2019. 116(51): p. 26049-26056.
15. Heng, Y., F. Lin, Y. Jiang, M. Ding, T. Yan, H. Lan, H. Zhou, X. Zhao, D. Xu, and X.W. Deng, B-Box Containing Proteins BBX30 and BBX31, Acting Downstream of HY5, Negatively Regulate Photomorphogenesis in Arabidopsis. Plant Physiol, 2019. 180(1): p. 497-508.
16. Ren, D., X. Wang, M. Yang, L. Yang, G. He, and X.W. Deng, A new regulator of seed size control in Arabidopsis identified by a genome-wide association study. New Phytol, 2019. 222(2): p. 895-906.
17. Ren, H., J. Han, P. Yang, W. Mao, X. Liu, L. Qiu, C. Qian, Y. Liu, Z. Chen, X. Ouyang, X. Chen, X.W. Deng, and X. Huang, Two E3 ligases antagonistically regulate the UV-B response in Arabidopsis. Proc Natl Acad Sci U S A, 2019. 116(10): p. 4722-4731.
18. Wang, L., M. Cheng, Q. Yang, J. Li, X. Wang, Q. Zhou, S. Nagawa, B. Xia, T. Xu, R. Huang, J. He, C. Li, Y. Fu, Y. Liu, J. Bao, H. Wei, H. Li, L. Tan, Z. Gu, A. Xia, X. Huang, Z. Yang, and X.W. Deng, Arabinogalactan protein-rare earth element complexes activate plant endocytosis. Proc Natl Acad Sci U S A, 2019. 116(28): p. 14349-14357.
19. Wang, X., M. Yang, D. Ren, W. Terzaghi, X.W. Deng, and G. He, Cis-regulated alternative splicing divergence and its potential contribution to environmental responses in Arabidopsis. Plant J, 2019. 97(3): p. 555-570.
20. Yu, X., J. Dong, Z. Deng, Y. Jiang, C. Wu, X. Qin, W. Terzaghi, H. Chen, M. Dai, and X.W. Deng, Arabidopsis PP6 phosphatases dephosphorylate PIF proteins to repress photomorphogenesis. Proc Natl Acad Sci U S A, 2019. 116(40): p. 20218-20225.
21. Dong, J., H. Chen, X.W. Deng, V.F. Irish, and N. Wei, Phytochrome B Induces Intron Retention and Translational Inhibition of PHYTOCHROME-INTERACTING FACTOR3. Plant Physiol, 2020. 182(1): p. 159-166.
22. Li, H., S. Jiang, C. Li, L. Liu, Z. Lin, H. He, X.W. Deng, Z. Zhang, and X. Wang, The hybrid protein interactome contributes to rice heterosis as epistatic effects. Plant J, 2020. 102(1): p. 116-128.
23. Li, J., W. Terzaghi, Y. Gong, C. Li, J.J. Ling, Y. Fan, N. Qin, X. Gong, D. Zhu, and X.W. Deng, Modulation of BIN2 kinase activity by HY5 controls hypocotyl elongation in the light. Nat Commun, 2020. 11(1): p. 1592.
24. Lin, Z., P. Qin, X. Zhang, C. Fu, H. Deng, X. Fu, Z. Huang, S. Jiang, C. Li, X. Tang, X. Wang, G. He, Y. Yang, H. He, and X.W. Deng, Divergent selection and genetic introgression shape the genome landscape of heterosis in hybrid rice. Proc Natl Acad Sci U S A, 2020. 117(9): p. 4623-4631.
25. Liu, H., R. Lin, and X.W. Deng, Photobiology: Light signal transduction and photomorphogenesis. J Integr Plant Biol, 2020. 62(9): p. 1267-1269.
26. Peng, X., M. Wang, Y. Li, W. Yan, Z. Chang, Z. Chen, C. Xu, C. Yang, X.W. Deng, J. Wu, and X. Tang, Lectin receptor kinase OsLecRK-S.7 is required for pollen development and male fertility. J Integr Plant Biol, 2020. 62(8): p. 1227-1245.
27. Qin, N., D. Xu, J. Li, and X.W. Deng, COP9 signalosome: Discovery, conservation, activity, and function. J Integr Plant Biol, 2020. 62(1): p. 90-103.
28. Song, Z., T. Yan, J. Liu, Y. Bian, Y. Heng, F. Lin, Y. Jiang, X.W. Deng, and D. Xu, BBX28/BBX29-HY5-BBX30/31 form a feedback loop to fine-tune photomorphogenic development. Plant J, 2020: p. doi: 10.1111/tpj.14929.
29. Wang, J., N. Sun, F. Zhang, R. Yu, H. Chen, X.W. Deng, and N. Wei, Differential Regulation of Arabidopsis PP2C-D1 by SAUR17 and SAUR50 in Apical Hook Development and Cotyledon Opening. Plant Cell, 2020: p. doi:10.1105/tpc.20.00283.
30. Wang, M., W. Yan, X. Peng, Z. Chen, C. Xu, J. Wu, X.W. Deng, and X. Tang, Identification of late-stage pollen-specific promoters for construction of pollen-inactivation system in rice. J Integr Plant Biol, 2020. 62(8): p. 1246-1263.
31. Wang, X., R. Yu, J. Wang, Z. Lin, X. Han, Z. Deng, L. Fan, H. He, X.W. Deng, and H. Chen, The Asymmetric Expression of SAUR Genes Mediated by ARF7/19 Promotes the Gravitropism and Phototropism of Plant Hypocotyls. Cell Rep, 2020. 31(3): p. 107529.
32. Xu, D. and X.W. Deng, CBF-phyB-PIF Module Links Light and Low Temperature Signaling. Trends Plant Sci, 2020: p. doi: 10.1016/j.tplants.2020.06.010.
33. Xu, D., D. Wu, X.H. Li, Y. Jiang, T. Tian, Q. Chen, L. Ma, H. Wang, X.W. Deng, and G. Li, Light and Abscisic Acid Coordinately Regulate Greening of Seedlings. Plant Physiol, 2020. 183(3): p. 1281-1294.
34. Yang, P., Q. Wen, R. Yu, X. Han, X.W. Deng, and H. Chen, Light modulates the gravitropic responses through organ-specific PIFs and HY5 regulation of LAZY4 expression in Arabidopsis. Proc Natl Acad Sci U S A, 2020. 117(31): p. 18840-18848.
35. Zhang, H., M. Wang, Y. Li, W. Yan, Z. Chang, H. Ni, Z. Chen, J. Wu, C. Xu, X.W. Deng, and X. Tang, GDSL esterase/lipases OsGELP34 and OsGELP110/OsGELP115 are essential for rice pollen development. J Integr Plant Biol, 2020: p. doi: 10.1111/jipb.12919.
36. Zhu, W., H. Zhou, F. Lin, X. Zhao, Y. Jiang, D. Xu, and X.W. Deng, COLD-REGULATED GENE 27 Integrates Signals from Light and the Circadian Clock to Promote Hypocotyl Growth in Arabidopsis. Plant Cell, 2020: p. doi: 10.1105/tpc.20.00192.
前期代表性论文：
1. Deng, X.W., and Gruissem, W. (1987). Control of plastid gene expression during development: the limited role of transcriptional regulation. Cell 49, 379-387.17(12):2246–2258
2. Deng, X.W., Matsui, M., Wei, N., Wagner, D., Chu, A.M., Feldmann, K.A., and Quail, P.H. (1992). COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain. Cell 71, 791-801.
3. Deng, X.W. (1994). Fresh view of light signal transduction in plants. Cell 76, 423-426.
4. Wei, N., Chamovitz, D.A., and Deng, X.W. (1994). Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell 78, 117-124.
5. von Arnim, A.G., and Deng, X.W. (1994). Light inactivation of Arabidopsis photomorphogenic repressor COP1 involves a cell-specific regulation of its nucleocytoplasmic partitioning. Cell 79, 1035-1045.
6. Chamovitz, D.A., and Deng, X.W. (1995). The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. Cell 82, 353-354.
7. Chamovitz, D.A., Wei, N., Osterlund, M.T., von Arnim, A.G., Staub, J.M., Matsui, M., and Deng, X.W. (1996). The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell 86, 115-121.
8. Osterlund, M.T., Hardtke, C.S., Wei, N., and Deng, X.W. (2000). Targeted destabilization of HY5 during light-regulated development of Arabidopsis.Nature 405, 462-466.
9. Wang, H., Ma, L.G., Li, J.M., Zhao, H.Y., and Deng, X.W. (2001). Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. Science 294, 154-158.
10. Schwechheimer, C., Serino, G., Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R.J., Gray, W.M., Estelle, M., and Deng, X.W. (2001). Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science292, 1379-1382.
11. Rubio, V., and Deng, X.W. (2005). Phy tunes: phosphorylation status and phytochrome-mediated signaling. Cell 120, 290-292.
12. Rubio, V., and Deng, X.W. (2007). Standing on the shoulders of GIGANTEA. Science 318, 206-207.
13. Feng, S., Martinez, C., Gusmaroli, G., Wang, Y., Zhou, J., Wang, F., Chen, L., Yu, L., Iglesias-Pedraz, J.M., Kircher, S., Schafer, E., Fu, X., Fan, L.M., and Deng, X.W. (2008). Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature 451, 475-479.
14. Wu, D., Hu, Q., Yan, Z., Chen, W., Yan, C., Huang, X., Zhang, J., Yang, P., Deng, H., Wang, J., Deng, X.W., and Shi, Y. (2012). Structural basis of ultraviolet-B perception by UVR8. Nature 484, 214-219.
学术兼职及社会服务：
美国植物生理学家协会(American Society of Plant Physiologists)会员
美国科学发展促进会 (American Society for the Advancement of Science)会士
2011年植物光生物学国际研讨会(The 2011 International Symposium of Plant Photobiology)组织者
第18届国际拟南芥研究大会(The 18th International Conference on Arabidopsis Research)组织者、主席(2007年)
The Arabidopsis Information Research (TAIR) 顾问委员会成员(2006-2008年)
Multinational Arabidopsis Research Committee主席(2007-2008年)
Multinational Arabidopsis Research Committee共同主席(2006-2007年)
North American Arabidopsis Research Steering Committee主席(2007-2008年)
North American Arabidopsis Research Steering Committee成员(2004-2008年)
Ohio State Arabidopsis Stock Center科学顾问委员会成员(2003-2006年)
MPI(德国马普伴郎替新郎试车吴梦梦)for Plant Breeding Research科学顾问委员会成员(2003-2008年)
Scientific Review Group Member for Samsbury Laboratory成员(2003年)
“Plant Cell” 期刊编委(2008年至2014年)
“Annual Review of Plant Biology” 期刊编委(2010-2012年)
“Plant Journal” 期刊编委(2000-2005年)
“Molecular Plant” 期刊顾问委员会成员(2006年至今)
“Journal of Integrated Plant Biology” 期刊编委(2004年至今)
“Plant Molecular Biology” 期刊编委(1998年至2018)
“Genes to Cell” 期刊编委(2000年至2018)